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You must know that alcohol consumption must be avoided while taking cozaar.

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Losartan selectively blocks the AT 1 receptorIn vitro and in vivo losartan and its pharmacologically active carboxylic acid metabolite E-3174 block all physiologically relevant actions of angiotensin IIregardless of the source or route of its synthesis.

Following oral administrationplasma concentrations of losartan and its active metabolite decline polyexponentiallywith a terminal half-life of about 2 hours and 6-9 hoursrespectivelyDuring once-daily dosing with 100 mgneither losartan nor its active metabolite accumulates significantly in plasma.

Fetal toxicity may developdiscontinue if pregnancy is detectedCorrect salt/volume depletion before starting therapyor reduce initial doseRenal impairmentmonitor for worsening renal functionHepatic impairmentSevere CHFRenal artery stenosisPregnancyCat.DNursing mothersnot recommended.

In rare casesCozaar can cause a condition that results in the breakdown of skeletal muscle tissueleading to kidney failureCall your doctor right away if you have unexplained muscle paintendernessor weakness especially if you also have feverunusual tirednessand dark colored urine.

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