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There are three basic mechanisms involved in normal ante-grade ejaculationemissionexpulsionand orgasmand each of these components possesses separate neural pathwaysEjaculatory dysfunction can result from disruption of any point in this cascade of eventsSeveral recent studies have clarified some aspects of the physiology of ejaculationEmissionwhich begins with closure of the bladder neck to prevent retrograde flow of seminal fluid and sperm into the bladderrefers to the deposition of seminal fluid and sperm from the distal epididymisvas deferensseminal vesiclesand prostate into the posterior urethraWitt and Grantmyre 1993
Plasma concentration profiles of dapoxetine after administration of a single dose or multiple doses of dapoxetine 30 mgaand dapoxetine 60 mgbModi et al2006
AbbreviationsIELTintravaginal ejaculatory latency timePEpremature ejaculation.
Overall10of the men continued taking dapoxetine for the entire two yearsDiscontinuation rates increased over timeJust over a quarter of the men stopped therapy during the first monthIn 6 months79had stopped taking dapoxetineand by 24 monthsthe rate was 90
Dapoxetinea novel selective serotonin transport inhibitor for the treatment of premature ejaculation.
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