If any patients are taking zyvox for longer than the recommended 28 days, their visual function should be regularly monitored.
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Bullous disorders such as those described as Stevens-Johnson syndrome and toxic epidermal necrolysisangioedemaalopecia.
You should become very familiar with the list of foods you must avoid while you are using linezolid.
This drug may rarely cause an attack of extremely high blood pressurehypertensive crisiswhich may be fatalMany drug and food interactions can increase this risksee How to Use and Drug Interactions sectionsGet medical help right away if any of these serious side effects occursevere headachefast/slow/irregular/pounding heartbeatchest painneck stiffness/sorenesssevere nausea/vomitingsweating/clammy skinsometimes with feverwidened pupilsvision changessuch as double/blurred visionsudden sensitivity to lightphotophobia
Linezolid concentrations have been determined in various fluids from a limited number of subjects in volunteer studies following multiple dosingThe ratio of linezolid in saliva and sweat relative to plasma was 1.2:1.0 and 0.55:1.0respectivelyThe ratio for epithelial lining fluid and alveolar cells of the lung was 4.5:1.0 and 0.15:1.0when measured at steady-state CmaxrespectivelyIn a small study of subjects with ventricular-peritoneal shunts and essentially non-inflamed meningesthe ratio of linezolid in cerebrospinal fluid to plasma at Cmax was 0.7:1.0 after multiple linezolid dosing.
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in addition, zyvox does not inhibit the activities of clinically significant human cyp isoforms e.